Rahn's Defensil-Pure Eco Pre/Post-biotic Supports 'Preservative-free,' Anti-inflammasome Skin Care | Cosmetics & Toiletries
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Rahn's Defensil-Pure Eco Pre/Post-biotic Supports 'Preservative-free,' Anti-inflammasome Skin Care | Cosmetics & Toiletries

Mar 22, 2025

Beauty innovators continually face increasing restrictions on the preservative systems used in formulations. As such, Rahn Cosmetic Actives introduced a version of its renowned post-biotic active, Defensil-Pure Eco, that features pentylene glycol as a "mild, non-listed preservative." What's more, the ingredient has been shown to counteract the activation of the skin's inflammasome, and to "regenerate the skin immediately after just one application."

Defensil Pure-Eco (INCI: Water (Aqua) (and) Pentylene Glycol (and) Panicum Miliaceum (Millet) Seed Extract (and) Lactobacillus Ferment) is a water-based, fermented millet extract. Designed for especially dry skin, it reportedly hydrates and strengthens the skin barrier immediately after application.

According to the company, dry and atopic skin suffers regularly from physical damage and a weakened barrier. This makes the skin vulnerable to bacteria entering the deeper layers, which can cause adverse inflammatory reactions by activating the inflammasome.

Clinical studies have shown that Defensil-Pure Eco can protect dry and atopic skin against further damage by quickly regenerating skin and "resealing" the barrier, per Rahn.

Also, per the company, in vitro, Defensil-Pure Eco serves as a prebiotic, promoting the growth of beneficial bacteria on skin to displace undesirable microorganisms.

Its postbiotic output is also said to effectively inhibit the activation of the inflammasome. Indeed, an analysis of the fermented millet extract reportedly showed that fermentation results in a greater release of important minerals, compared with standard millet extract.

Taken together, Defensil-Pure Eco has been scientifically substantiated, at 0.5-3.0%, to back claims such as: